Here's how to give a game its own profile, so PadForge switches to it when the game comes to the front. You're hearing a generated voice.

Set PadForge up the way you want for the game. Then open the Profiles page, and click Save As.

Name it after the game. Click Browse, and pick the game's program. Here, Character Map stands in for a game. Then click Save.

Tick Auto-Switch Profiles Based on Foreground Application. The Foreground line shows the program in front.

Bring the game to the front, and PadForge loads its profile. The program's name lights up while it matches.

Switch to anything else, and PadForge goes back to Default. Changes you make save into whichever profile is loaded.

Find more guides at padforge.org.